Well, I’m not Beeple, but I’ll try to answer the question anyway.
Honestly I’ve done it all — 4 monitors in a 2x2 grid, four side by side, two side by side, two side by side and one vertical. Honestly, what I took away from the experience is that monitor space is like the size of a bowl for goldfish. You’ll pretty much always stretch out and figure out how to use screen real estate
When I simplified things down, I found I was happiest with one UWD, and a small second monitor off to the right. It’s well suited for graphic design work, cus I can keep a document or Slack open on a small monitor and have a full UWD to handle all my toolbars and stuff.
Pretty rich listening to Trump whine about his civil rights. All those kids in cages on the Mexican border didn’t have shit for civil rights, did they.